The eight story Kalamazoo National Bank Building is recognized as the city's first skyscraper. When it opened in 1907 the primary tenant was the Kalamazoo National Bank. Its upper floors housed a variety of small businesses.

The Kalamazoo National Bank Building would eventually be overshadowed by the 10 story Hanselman Building across the street. The Kalamazoo National Bank moved out in 1929. Thereafter the building has been called the Kalamazoo Building. In the 1960's the classical exterior was altered with the removal of the cornice followed by alterations to the facades. It is currently occupied by Keystone Bank.